Bristol Myers Squibb and Bluebird Bio are seeking U.S. approval of their lead investigational CAR T-cell therapy — idecabtagene vicleucel (ide-cel; bb2121) — for the treatment of heavily pre-treated multiple myeloma. The companies have submitted a biologics license application to the U.S. Food and Drug Administration for ide-cel’s approval to treat adult patients, who have received at least three prior lines of cancer therapy, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 antibody. Chimeric antigen receptor T-cell therapy, more commonly known as CAR T-cell therapy, is a type of immunotherapy in which a patient’s T-cells — immune cells with anti-cancer activity — are collected and re-engineered in the lab to better recognize and eliminate cancer cells. The modified…
April 14, 2020April 14, 2020