Langerhans Cells Protect Skin Tumors from Radiation Treatment

Researchers at the Tish Cancer Institute, Icahn School of Medicine at Mount Sinai, have discovered how tumors can survive the effects of radiotherapy. While studying skin tumors, the team discovered that during radiotherapy, skin immune cells — called Langerhans cells — are activated to repair the DNA damage caused by the radiation. When Langerhans cells were exposed to radiation, they could repair their own DNA. The cells then activated regulatory T cells — an immune cell type designated to dampen…

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