A small inhibitor that prevents cells from making ribosomes — the machinery used to produce proteins — may improve the effectiveness of PARP inhibitors in ovarian cancers with mutations in DNA repair genes, a study in mice found. This inhibitor is a promising approach for ovarian cancers that are no longer susceptible to platinum-based chemotherapy or PARP inhibitors. The study with this finding, “CX-5461 activates the DNA damage response anddemonstrates therapeutic efficacy in high-gradeserous ovarian cancer,” was…
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