Amyloid-beta produced in peripheral organs, specifically the liver, may be implicated in the brain neurodegeneration observed in Alzheimer’s disease, according to a mouse study. The study, “Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype,” was published in PLOS Biology. Deposits of amyloid-beta in the brain are a hallmark of Alzheimer’s. However, given that both the brain and liver produce amyloid-beta, it has been challenging for scientists to determine the source…
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