AC Immune has announced it will extend its partnership with researchers at the University of Pennsylvania to further study the mechanisms underlying disease-causing changes in the transactive response DNA binding protein 43 kDa (TDP-43). Specifically, company researchers and those with the university’s Center for Neurodegenerative Disease Research at the Perelman School of Medicine are looking into what causes TDP-43 misfolding, aggregation, and cell-to-cell transmission. Over the last two years, this collaboration has shown that TDP-43 aggregates in the brain have…
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