Every participant in the Phase 2/3 GAIN clinical trial, which is testing Cortexyme’s experimental medication COR388 (atuzaginstat) in people with Alzheimer’s disease, showed evidence of infection by Porphyromonas gingivalis (P. gingivalis), according to a new analysis. In particular, all patients analyzed at the beginning of the study who had available data on their cerebrospinal fluid — the liquid that surrounds the brain and spinal cord — were positive for antibodies against P. gingivalis, supporting a direct…
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