This post was originally published on this site Chronic B-cell activation — which can happen because of infectious mononucleosis, commonly caused by the Epstein-Barr virus (EBV) — triggers an excessive proliferation of certain B cells, which can evolve into a B-cell lymphoma. Although such chronic activation alone is not sufficient to drive cancer onset, vaccinating against EBV may work to…
This post was originally published on this site Melanomas with a high number of genetic mutations that lead to over-activation of the nuclear factor-κB (NF-κB) signaling cascade — a family of gene expression regulators — are about three times more likely to respond to treatment with checkpoint blockade immunotherapies, according to a study. The findings…
This post was originally published on this site 68Ga-PSMA-11 PET scans are highly accurate, reproducible, and safe for detecting prostate cancer that has come back after prior therapy with prostate surgery or radiation therapy, a study shows. The report, “Assessment of 68Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer,” was published in the journal JAMA Oncology.…
This post was originally published on this site A combination of Lynparza (olaparib) and the investigational PI3K inhibitor alpelisib is safe for the treatment of recurrent epithelial ovarian cancer and induces at least stable disease in more than 80% of patients, results from a Phase 1 trial show. Importantly, the combination was effective in women…
This post was originally published on this site During April, National Sarcoidosis Awareness Month, the Society for Cardiovascular Magnetic Resonance (SCMR) is promoting the use of cardiac imaging to non-invasively assess changes in patients’ heart tissue and overall cardiac function. Sarcoidosis is marked by an overreactive immune system and the resulting formation of small clumps of…
This post was originally published on this site It’s been a tumultuous year so far (to say the least). I write this while lying sprawled out on a deck chair in the garden, watching as the African sun slips beneath the horizon of the Atlantic Ocean. I’m on a two-week holiday to my native city…
This post was originally published on this site Clofazimine, an antibiotic long used for treating leprosy and tuberculosis, may be repurposed as a promising potential treatment for triple-negative breast cancer, a study in mice suggests. The treatment targets the Wnt signaling pathway – key in triple-negative breast and other cancer types – preventing cells from growing,…
This post was originally published on this site The Muscular Dystrophy Association (MDA) has recently added to its research team an expert in neurological diseases in order to enhance and improve its healthcare service programs. MDA has hired Lianna R. Orlando, Scientific Program Officer who comes to MDA from Fidelity Biosciences Research Initiative. There at Fidelity, she…
This post was originally published on this site Researchers from the University of Helsinki recently found that a vitamin B3 form might be effective in attenuating the progression of mitochondrial myopathy. The study is published in the journal EMBO Molecular Medicine. Mitochondrial disorders are caused by respiratory chain deficiency (RCD) and are the most usual…
This post was originally published on this site Cellectis announced plans to open a Phase 1 clinical trial to evaluate UCARTCS1 — its first allogeneic (donor-derived) CAR T-cell therapy for multiple myeloma patients — at several sites in the U.S. The trial, called MUNDI-01, will assess multiple doses of the therapy to determine its safety, cell expansion and persistence,…
