This post was originally published on this site The Alzheimer’s Drug Discovery Foundation (ADDF) has awarded $1.5 million to Oryzon Genomics to support expanding an ongoing Phase 2a trial assessing the potential of vafidemstat (ORY-2001) in patients with mild to moderate Alzheimer’s disease to the United States. The double-blind, placebo-controlled trial (2017-004893-32), called ETHERAL, is…
About Alzheimer’s Disease
Walking into a room and forgetting why you went into the room is normal. Walking into a room and forgetting what room you are in is not normal. Alzheimer’s disease is the most common form of dementia and affects one in ten people over the age of 65. Unfortunately, the exact cause of Alzheimer’s disease is not fully understood however leading scientific experts in the field attribute the illness to the irreversible and progressive generalized degeneration of the brain. Alzheimer’s disease goes well beyond the forgetfulness that may accompany aging, and typically first signs include difficulty remembering current information or performing new tasks. Ongoing hallmark symptoms include impaired memory function, difficulty performing everyday tasks, and neurobehavioral abnormalities. Currently, there is no known cure for Alzheimer’s disease, and multi-disciplinary treatment focuses on symptom management and limiting progression.
Conditions
Alzheimer’s News
PRI-002, Oral Therapy Candidate for Alzheimer’s, Deemed Safe in Phase 1 Trial
This post was originally published on this site Alzheimer’s oral therapy candidate PRI-002, being developed by Priavoid, has proven safe for human use in healthy volunteers during a Phase 1 clinical trial. These positive trial results provide important evidence that supports progressing PRI-002 into studies of patients who have Alzheimer’s disease. “Our next goal is the…
Investigational Alzheimer’s Therapy NNI-362 Receives FDA Approval to Enter Phase 1 Clinical Studies
This post was originally published on this site The U.S. Food and Drug Administration has approved Neuronascent’s investigational new drug (IND) application for NNI-362, its therapy candidate for Alzheimer’s disease, allowing it to move ahead with a Phase 1a clinical trial, the company announced. The first-in-human trial will evaluate the safety of NNI-362 in healthy…
Caregivers Can Help Preserve Alzheimer’s Patients’ Dignity
This post was originally published on this site Dignity diminished Alzheimer’s disease has a way of robbing a person’s dignity. Given enough time, it strips away what is basic to our loved one’s personality, including the very characteristics associated with dignity. It replaces their normal reserve, appearance, language, and seriousness of manner with odd behavior…
2 Planned Clinical Trials to Test Ways of Preventing Alzheimer’s at Early Stages
This post was originally published on this site Elenbecestat and BAN2401, two potential anti-amyloid therapies, were selected by the Alzheimer’s Clinical Trials Consortium (ACTC) to be evaluated in clinical studies aiming to prevent progression to early stages of Alzheimer’s disease. ACTC is a network of 35 primary clinical trial sites across the U.S., established by the…
Sleep Molecules May Represent a New Blood Biomarker for Earlier Diagnosis, Study Suggests
This post was originally published on this site High blood levels of primary fatty acid amides (PFAMS), a class of fatty molecules involved in sleep and movement control, are associated with increased accumulation of beta-amyloid protein in the cerebrospinal fluid of patients with Alzheimer’s disease, a study finds. Researchers believe that this class of fatty…
UNC Launches Training Program to Improve Dementia Patients’ Care
This post was originally published on this site A new program called the Dementia Friendly Hospital Initiative is set to be launched in North Carolina to raise awareness among healthcare providers on how patients with Alzheimer’s disease and dementia experience care interventions and how to meet their needs. Led by the University of North Carolina…
Despite Alzheimer’s, My Mom Never Lost Sight of Motherhood
This post was originally published on this site I recently discovered this article celebrating Mother’s Day and found it to be an enjoyable read because it rings true for me. Honest Abe earned his nickname All of us tend to be sentimental about our moms. Inspired by wonderful mothers, many of us could write 100…
Family Caregivers of Dementia Patients May Benefit from Learning Positive Emotion Skills, Study Suggests
This post was originally published on this site An online program that teaches how to focus on positive emotions can help caregivers of family members with dementia to cope better with stress, and reduce their depression and anxiety symptoms, results from a clinical study suggest. The six-week skill-building intervention, called Life Enhancing Activities for Family…
Tetra Launches Phase 2 Trial Testing Treatment to Improve Working Memory in Older Patients
This post was originally published on this site Tetra Discovery Partners is launching a Phase 2 clinical trial for BPN14770 — found to improve working memory in older patients in earlier trials — as a treatment for people with early stage Alzheimer’s disease. The trial, called PICASSO AD (NCT03817684), is recruiting in about 60 clinical…
#AANAM – Memantine as Add-on Therapy Seen to Ease Psychosis, Other Advanced Alzheimer’s Symptoms
This post was originally published on this site Adding memantine to a cholinesterase inhibitor can significantly ease certain neuropsychiatric symptoms, including psychosis and troubling motor or nighttime behavior, in people with moderate-to-severe Alzheimer’s disease, according to pooled data from three Phase 3 clinical trials. But it was not seen to be of any benefit in…
Caregivers Face Isolation, but You Can Find Ways to Connect
This post was originally published on this site Caregivers are often isolated. This may be particularly true of those who provide care for loved ones in the late stages of Alzheimer’s disease. As it progresses, patients are less likely to get out and about. Every day they lose a little bit of their freedom, and…