This post was originally published on this site Myopia, which affects the muscles used to focus the lens of the eye, appears to have clinical implications for “accommodating,” or focusing, intraocular lens (IOLs) implants that help the eye adapt to different visual distances, according to a study in the journal Optometry and Vision Science, titled “The Effect of Age,…
About Alzheimer’s Disease
Walking into a room and forgetting why you went into the room is normal. Walking into a room and forgetting what room you are in is not normal. Alzheimer’s disease is the most common form of dementia and affects one in ten people over the age of 65. Unfortunately, the exact cause of Alzheimer’s disease is not fully understood however leading scientific experts in the field attribute the illness to the irreversible and progressive generalized degeneration of the brain. Alzheimer’s disease goes well beyond the forgetfulness that may accompany aging, and typically first signs include difficulty remembering current information or performing new tasks. Ongoing hallmark symptoms include impaired memory function, difficulty performing everyday tasks, and neurobehavioral abnormalities. Currently, there is no known cure for Alzheimer’s disease, and multi-disciplinary treatment focuses on symptom management and limiting progression.
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Alzheimer’s News
Alcon Granted European Approval for Preloaded Intraocular Lens Delivery System
This post was originally published on this site Alcon, a Novartis sub-arm specializing in eye care, has announced it received European CE Mark for its AcrySof IQ Aspheric IOL with the UltraSert Pre-loaded Delivery System for patients undergoing cataract surgery. This approval comes right after Alcon’s CE Mark for its trifocal presbyopia-correcting AcrySof IOL, in June 2015. The new…
Extract from Native California Plant Shows Neuroprotective Ability Against Alzheimer’s, Study Reports
This post was originally published on this site Sterubin, an active chemical compound extracted from a native California plant, was found to hold neuroprotective and anti-inflammatory potential for Alzheimer’s disease, a study shows. The study, “Old age-associated phenotypic screening for Alzheimer’s disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa,” was…
AlzProtect’s Candidate Therapy AZP2006 Well-tolerated in Healthy Volunteers, Phase 1 Trial Shows
This post was originally published on this site A Phase 1 clinical trial in healthy volunteers for investigational therapy AZP2006 — an oral medicine that is meant to clear accumulations of toxic proteins in Alzheimer’s disease and progressive supranuclear palsy — has shown positive results, says the therapy’s developer, AlzProtect. Progressive supranuclear palsy (PSP) is a rare, progressive disease…
Denali–Sanofi Partnership Dosing Alzheimer’s Patients in DNL747 Clinical Trial
This post was originally published on this site Denali Therapeutics has begun dosing patients in its Phase 1b clinical trial of DNL747 as a treatment for Alzheimer’s disease. “We are excited to advance DNL747 in a second neurodegeneration indication based on Phase 1 healthy volunteer data regarding DNL747’s safety profile, CNS [central nervous system] penetration, and target engagement, at the…
Phase 2 Trial of Tau Antibody RO7105705 Recruiting Patients with Moderate Alzheimer’s
This post was originally published on this site A Phase 2 trial is enrolling patients with moderate Alzheimer’s to test an investigational antibody known as RO7105705 that targets the Tau protein. The Genentech-sponsored multicenter, randomized study (NCT03828747) intends to assess the efficacy, safety, and pharmacological profile of RO7105705. The company plans to recruit 260 patients…
Massachusetts Journalist With Alzheimer’s Discusses Life’s Challenges in Podcast
This post was originally published on this site All his life, Greg O’Brien has had a front-row seat for Alzheimer’s disease. Growing up on Cape Cod, Massachusetts, he was the caregiver in a family of 10 children for his mother. His maternal grandfather and paternal uncle had Alzheimer’s, and his father was diagnosed with dementia…
Alzheimer’s Animal Studies Examine Lack of ‘Cleaning’ in Brain Cells
This post was originally published on this site Boosting mitophagy — a natural process that clears neurons from damaged mitochondria (cells’ energy powerhouses) — decreased amyloid plaque formation and reversed cognitive deficits, namely memory impairments, across different animal models of Alzheimer’s disease (AD). “When the cleaning system does not work properly, there will be an…
Anti-epileptic Therapy Not Linked to Increased Dementia Risk, Study Reports
This post was originally published on this site Use of anti-epileptic therapy is not linked to an increased risk of dementia, according to the results of a real-world study with more than 100,000 patients followed in general and neuropsychiatrist practices in Germany. However, generic forms of the anti-epileptic medicine levetiracetam may potentially have a deleterious…
HIV Therapy May to Help Stop ‘Jumping Gene’ Linked to Inflammation Associated with Aging
This post was originally published on this site HIV therapies that block an enzyme that is essential for viruses to replicate, called reverse transcriptase, may offer a new way of treating age-related disorders like Alzheimer’s, a study suggests. The study, “L1 drives IFN in senescent cells and promotes age-associated inflammation,” was published in the journal…
Education Does not Improve Adaptability of Brain in Old Age, Study Suggests
This post was originally published on this site A higher level of education is not related to better cognitive reserve — the ability of the adult brain to maintain normal cognitive function in the presence of neurodegeneration — in old age, a study suggests. However, the study, titled “Education and cognitive reserve in old age,” did find that it allowed…
Brain Metabolism of Hibernating Hamsters May Reveal Novel Therapeutic Targets for Alzheimer’s Disease
This post was originally published on this site Upon hibernation, the brains of Syrian hamsters undergo metabolic changes that involve the phosphorylation of tau protein — a hallmark of Alzheimers’ disease. However, this process is rapidly reversed upon waking and understanding it could lead to the development of new therapies for Alzheimer’s, a study suggests. The…