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About Cancer

Cancer, also called malignancy, is an abnormal growth of cells with the potential to invade or spread to surrounding tissues and structures found within the body. There are more than 100 types of cancer. A few examples include breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. According to the American Cancer Society, 4 out of 10 people will be diagnosed with some form of cancer in their lifetime. Cancer prevalence has given rise to multiple medical specialties focused on symptom management and disease management. Current treatment options depending on the form of cancer include chemotherapy, radiation, blood or bone marrow transfusions, and/or surgery. Lifetime prognosis of cancer mortality is dependent on the type of cancer and is heavily conditional to early detection.

Cancer News

Darzalex Delays Disease Progression After ASCT, Phase 3 Trial Reports

Darzalex Delays Disease Progression After ASCT, Phase 3 Trial Reports

First-line maintenance therapy with Darzalex (daratumumab) significantly delays disease progression or death in adults with multiple myeloma who responded to autologous stem cell transplant (ASCT), according to data from the CASSIOPEIA trial’s second part. These findings, from a pre-planned interim analysis conducted by an independent data monitoring committee, indicate that the Phase 3 trial met the main goals of both its…

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Opdivo-Cabometyx Granted FDA Priority Review for Newly Diagnosed Advanced Kidney Cancer

Opdivo-Cabometyx Granted FDA Priority Review for Newly Diagnosed Advanced Kidney Cancer

The U.S. Food and Drug Administration (FDA) has agreed to review applications requesting the approval of Opdivo (nivolumab) in combination with Cabometyx (cabozantinib) for people with advanced renal cell cancer, the most common type of kidney cancer in adults. The applications — requests to extend the indications for Opdivo by Bristol Myers Squibb and Cabometyx by Exelixi — were given priority…

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Oncopeptides Will Seek Conditional Approval of Melflufen in Europe

Oncopeptides Will Seek Conditional Approval of Melflufen in Europe

Oncopeptides soon will seek conditional approval of melflufen (melphalan flufenamide) in the EU for the treatment of relapsed or refractory multiple myeloma. The pharmaceutical company now is planning to submit its application — some two years earlier than expected — to the European Medicines Agency (EMA) to request melflufen’s conditional approval. The request was originally intended to…

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Cancer Vaccine UV1 Plus Keytruda Shows Safety, Early Efficacy in Advanced Melanoma Trial

Cancer Vaccine UV1 Plus Keytruda Shows Safety, Early Efficacy in Advanced Melanoma Trial

Adding UV1, Ultimovacs’ experimental cancer vaccine, to Keytruda (pembrolizumab) is safe and shows initial signs of effectiveness in adults with previously untreated metastatic melanoma, according to top-line data from a Phase 1 clinical trial. “The safety profile observed to date in this first cohort [group of patients] of the [UV1-Keytruda] combination study is consistent with the promising…

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ADT Not Needed With Radiation in Favorable Intermediate-Risk PC

ADT Not Needed With Radiation in Favorable Intermediate-Risk PC

Adding four months of androgen deprivation therapy (ADT) to radiation treatment extends survival and delays metastasis in men with unfavorable intermediate-risk prostate cancer, according to a secondary analysis of a Phase 3 clinical trial. However, that new trial analysis showed there were no such benefits to ADT therapy for men with favorable intermediate-risk prostate cancer undergoing…

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FDA Places PC14586, for Cancers with Mutant Protein, on Fast Track

FDA Places PC14586, for Cancers with Mutant Protein, on Fast Track

The U.S. Food and Drug Administration (FDA) has granted fast track designation to PC14586 as a potential treatment of advanced cancers that harbor a specific mutation affecting the protein p53, which includes some ovarian cancers. Fast track is given to support therapies with the potential to fill a serious unmet medical need. They are eligible…

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COVID-19 Surgery Delays May Mean 2,700 More Breast Cancer Deaths Within 10 Years

COVID-19 Surgery Delays May Mean 2,700 More Breast Cancer Deaths Within 10 Years

Delays in breast cancer surgery due to the COVID-19 pandemic could cost 2,797 additional deaths in the U.S. over the next decade, according to a Kantar Health analysis. Such treatment delays also place patients at a higher risk of metastasis, or cancer spread, potentially increasing healthcare costs in the U.S. by an estimated $376 million…

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Sarclisa Triple Combo Conditionally Approved for NHS Use in England, Wales

Sarclisa Triple Combo Conditionally Approved for NHS Use in England, Wales

After first rejecting a Sarclisa (isatuximab) triple combination therapy due to cost-effectiveness concerns, the U.K.’s National Institute for Health and Care Excellence (NICE) has given conditional approval to the treatment for relapsed or refractory multiple myeloma. The triple therapy includes Sarclisa in combination with Imnovid (pomalidomide, also sold as Pomalyst) and dexamethasone, a corticosteroid. It is particularly recommended for…

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Committee Recommends EU Approval of Opdivo to Treat Advanced Esophageal Cancer

Committee Recommends EU Approval of Opdivo to Treat Advanced Esophageal Cancer

A committee of the European Medicines Agency has recommended the approval of Opdivo (nivolumab) for the treatment of people with advanced, inoperable, recurrent, or metastatic esophageal squamous cell carcinoma (ESCC) who previously received a chemo regimen containing fluoropyrimidine and a platinum agent. The European Commission will review this opinion from the Committee for Medicinal Products for Human…

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Provenge Improves Survival in mCRPC Patients Over Xtandi, Zytiga, Real-world Study Finds

Provenge Improves Survival in mCRPC Patients Over Xtandi, Zytiga, Real-world Study Finds

Provenge (sipuleucel-T), by Dendreon Pharmaceuticals, is superior to Zytiga (abiraterone acetate) or Xtandi (enzalutamide) at prolonging the lives of men with metastatic castration-resistant prostate cancer (mCRPC) when added at any point in a treatment regimen, according to a real-life study in the U.S. The study, “A Retrospective Observational Analysis of Overall Survival with Sipuleucel-T in…

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Phase 1 Trial of SL-172154 in Treating Advanced Ovarian Cancer Opens

Phase 1 Trial of SL-172154 in Treating Advanced Ovarian Cancer Opens

Shattuck Labs has opened a Phase 1 clinical trial to investigate its lead candidate, SL-172154, in treating people with advanced ovarian cancer, the company announced in a press release. The trial (NCT04406623) is recruiting up to 33 patients at three sites in the U.S.: the John Wayne Cancer Institute at Providence St. John’s Health Center in California,…

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Tecartus Recommended for EU Approval as CAR T-cell Therapy for Mantle Cell Lymphoma

Tecartus Recommended for EU Approval as CAR T-cell Therapy for Mantle Cell Lymphoma

A committee of the European Medicines Agency (EMA) has recommended the conditional approval of Tecartus (brexucabtagene autoleucel) for the treatment of adults with relapsed or refractory mantle cell lymphoma (MCL). The recommendation by the Committee for Medicinal Products for Human Use (CHMP) for Kite Pharma‘s CAR T-cell therapy is specific for patients who received at least two…

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