The American Urological Association (AUA), American Society for Radiation Oncology (ASTRO), and Society of Urologic Oncology (SUO) have released new guidelines for the diagnosis and treatment of advanced prostate cancer, the associations announced. These guidelines were developed by a panel of experts that a patient advocate. In addition to their own expertise and experience, panel…
About Cancer
Cancer, also called malignancy, is an abnormal growth of cells with the potential to invade or spread to surrounding tissues and structures found within the body. There are more than 100 types of cancer. A few examples include breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. According to the American Cancer Society, 4 out of 10 people will be diagnosed with some form of cancer in their lifetime. Cancer prevalence has given rise to multiple medical specialties focused on symptom management and disease management. Current treatment options depending on the form of cancer include chemotherapy, radiation, blood or bone marrow transfusions, and/or surgery. Lifetime prognosis of cancer mortality is dependent on the type of cancer and is heavily conditional to early detection.
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New Risk Calculator May Help Men With High PSA Decide on Having Prostate Biopsy
A new risk calculator may help men with high levels of prostate-specific antigen (PSA) — a marker of prostate cancer — to decide if they should undergo a prostate biopsy to determine if they have cancer. The cancer risk calculator, developed by researchers at Kaiser Permanente Northern California, is specifically designed to calculate the risk…
First AI-based Cancer Detection Application Slated for UK Rollout
Ibex Medical Analytics and LDPath have announced the rollout of the first clinical-grade artificial intelligence (AI) applications for pathology-based prostate cancer detection in the U.K. The new apps will aid in improving the accuracy and increasing the efficiency of cancer diagnostics, the companies said. Traditionally, cancer is diagnosed with the aid of a pathologist — an…
Celyad to Begin Phase 1 Trial of Donor-derived CAR T-cell Therapy for Multiple Myeloma
The U.S. Food and Drug Administration (FDA) has given Celyad Oncology permission to begin a Phase 1 clinical trial of CYAD-211, an investigational treatment for relapsed or refractory multiple myeloma. The trial is expected to commence by year’s end. “The FDA’s permission to begin the Phase 1 clinical trial of our lead shRNA-based allogeneic candidate…
First Patient Dosed in Trial Testing Belantamab Mafodotin, Nirogacestat Combo in RRMM Patients
A Phase 1b clinical trial evaluating GlaxoSmithKline (GSK)’s belantamab mafodotin, in combination with SpringWorks Therapeutics’ nirogacestat, in people with relapsed or refractory multiple myeloma, has dosed its first patient, SpringWorks announced. The safety and preliminary effectiveness of this combination are being assessed as a sub-study in GSK’s ongoing DREAMM-5 platform trial (NCT04126200). “We are delighted to…
EU Approval Urged for GSX’s Belantamab Mafodotin for Heavily Treated Myeloma
GlaxoSmithKline’s investigational therapy belantamab mafodotin has been recommended for approved in the European Union, by the Committee for Medicinal Products for Human Use (CHMP), for heavily treated multiple myeloma patients. The marketing authorization application, accepted for review in February, is specific for people with relapsed or refractory disease who were previously treated with an immunomodulatory agent, a proteasome…
$1.9M Grant Awarded for Study on How Fat Cells Help Myeloma Cells Resist Treatment
A new research project aiming to better understand how fat cells help multiple myeloma cells resist treatment has won a $1.9 million grant from the National Cancer Institute of the National Institutes of Health. The five-year funding was awarded to Michaela Reagan, PhD, a faculty scientist at the Maine Medical Center Research Institute (MMCRI), whose…
Sarclisa Triple Combo Prolongs Life Without Disease Progression in Some Myeloma Patients, Interim Data Show
A combination of Sarclisa (isatuximab) plus standard Kyprolis (carfilzomib) and dexamethasone treatment significantly delays disease progression or death in people with relapsed or refractory multiple myeloma, interim results from a Phase 3 clinical trial suggest. The findings were shared at the European Hematology Association (EHA) 2020 Virtual Congress, in a presentation titled, “Isatuximab plus carfilzomib and dexamethasone…
FDA Approves Tecentriq Combo for Certain Advanced Melanomas
The U.S. Food and Drug Administration (FDA) has approved the immunotherapy Tecentriq (atezolizumab), in combination with Cotellic (cobimetinib) and Zelboraf (vemurafenib), for the treatment of BRAF V600 mutation-positive advanced melanoma. The decision comes after promising findings from IMSPIRE150 (NCT02908672), a Phase 3 trial in which the triple combination significantly extended the time patients lived without signs…
Yale Researcher Wins NIH Merit Award, Supporting Immunotherapy Work
The National Institutes of Health (NIH) has given an R37 Merit Award to support the work of Kurt Schalper, MD, PhD, in the field of immunotherapy for the next seven years. An estimated 5% of all NIH-funded researchers are selected to receive this multiyear merit award. Schalper, an assistant professor of pathology and medicine at…
CAR T-cell Therapy Tecartus Granted FDA Approval for Mantle Cell Lymphoma
The U.S. Food and Drug Administration (FDA) has granted accelerated approval to Kite Pharma’s CAR T-cell therapy Tecartus (brexucabtagene autoleucel) for adults with relapsed or refractory mantle cell lymphoma (MCL). The decision comes less than six months after the FDA accepted to analyze, under priority review status, Kite’s biologics license application, shortening review time from the standard 10…
Phase 3 Trial Launched to Test Cabometyx-Tecentriq in Advanced Kidney Cancer
Exelixis has launched a Phase 3 trial that will investigate the safety and efficacy of a combination therapy of Cabometyx (cabozantinib) and Tecentriq (atezolizumab) in people with advanced renal cell carcinoma (RCC) whose cancer progressed while being treated with an immune checkpoint inhibitor or shortly thereafter. The pivotal study, called CONTACT-03 (NCT04338269), aims to enroll approximately 500…