This post was originally published on this site Because a disproportionate number of Alzheimer’s disease patients and caregivers are women, the Alzheimer’s Association and The Women’s Alzheimer’s Movement (WAM) are leading a global movement to do something about it. Announced March 8 on International Women’s Day, efforts include a South by Southwest (SXSW) Conference &…
Conditions
Conditions
CARsgen to Begin CT053 Clinical Testing in China for Heavily Treated Myeloma Patients
This post was originally published on this site CT053, one of CARsgen Therapeutics‘ lead CAR T-cell therapies, soon will begin clinical testing in China for the treatment of patients with relapsed or refractory multiple myeloma, after the Chinese National Medical Products Administration (NMPA) cleared its investigational new drug (IND) application. In recent years, immunotherapy has gained…
Researchers Find Compounds that Kill Chemo-resistant Cancer Cells
This post was originally published on this site A new study reports the development of compounds that could be used as ovarian cancer treatment. These compounds are particularly promising because they may be able to affect cancer that is resistant to chemotherapy. The study, “Exploring the Cytotoxicity, Uptake, Cellular Response, and Proteomics of Mono- and…
Provenge Better for African-Americans Than Men of Other Ethnicities, Analysis Shows
This post was originally published on this site Provenge (sipuleucel-T), a treatment approved in the U.S. for metastatic castration-resistant prostate cancer, significantly increased the number of patients alive at three years, compared to a placebo, a retrospective analysis of Phase 3 clinical data shows. The treatment, which harnesses the immune system to fight cancer, was…
TC BioPharm, Trinity College Dublin Pair to Develop Cancer-fighting Cell Therapy
This post was originally published on this site TC BioPharm (TCB) and Trinity College Dublin researchers are working together to expedite the production of V delta 1 γδ T cells to be used in the fight against solid tumors. TCB’s in-house Good Manufacturing Practice (GMP) team will be working with Derek Doherty, an associate professor and head of immunology…
Phase 1/2 Trial of Tinostamustine to Treat Blood Cancers Opens 2nd Stage
This post was originally published on this site The expansion stage of a Phase 1/2 trial testing tinostamustine in relapsed or refractory types of lymphoma and other blood cancers has enrolled a first patient. The study (NCT02576496) is currently enrolling up to 65 patients in the U.S. and Europe with advanced multiple myeloma, Hodgkin’s lymphoma, peripheral T-cell…
Brexit Could Have Real Effects for UK Rare Disease Patients, Experts Warn
This post was originally published on this site Madeline Collin, a 24-year-old activist with Gaucher disease, worries that patients like her will suffer deeply if Britain leaves the European Union (EU), as scheduled, at the end of this month. Collin is an expert on the subject. For her University of Bathdissertation, she analyzed Brexit’s long-term…
Kyprolis Combo Yields Positive Results as Initial Treatment for Multiple Myeloma
This post was originally published on this site A combination of Kyprolis (carfilzomib) and dexamethasone, already approved for relapsed and refractory multiple myeloma, may also be effective and safe as a first-line treatment for newly diagnosed patients, according to a study. The dual combo yielded the highest response rates to date for a two-agent combination employed as…
Ultrasensitive Chip Detects Cancer Faster, Less Invasively than Current Approaches, Study Suggests
This post was originally published on this site Researchers have developed an ultrasensitive diagnostic device, a kind of “lab-on-a-chip,” that quickly detects cancer using a droplet of blood, potentially allowing for an easier, cheaper, and more timely cancer diagnosis. The device is described in the study, “Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip,”…
Brains of People with Sleep Apnea Show Increased Tau Protein Aggregates
This post was originally published on this site People with sleep apnea show increased accumulation of tau protein aggregates — a hallmark of Alzheimer’s disease — in brain regions linked to memory and spatial navigation, a study finds. The results will be presented during the 71st Annual Meeting of the American Academy of Neurology, May…
FDA Grants Accelerated Approval to Tecentriq-Abraxane Combo for Some TNBC
This post was originally published on this site The U.S. Food and Drug Administration has granted accelerated approval to a combination of Tecentriq (atezolizumab) and the chemotherapy Abraxane (nab-paclitaxel) for patients with advanced triple-negative breast cancer, making this the first immunotherapy regimen approved specifically for breast cancer. The approval, which is for patients whose tumors produce…
Vitamin C Might Reverse Stress-induced Driver of Breast Cancer, Study Says
This post was originally published on this site Chronic stress and the consequent release of the stress hormone epinephrine may help breast cancer cells grow by helping them get more energy, a study in mice shows. This effect might be reversed through treatment with vitamin C, researchers report. The study, “Stress-induced epinephrine enhances lactate dehydrogenase A…