This post was originally published on this site A connection discovered between Alzheimer’s and the bacteria that cause gum disease suggests that improved oral hygiene may decrease the risk of developing the disorder, a study reports. The study, “Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors,” was published…
Conditions
Conditions
FDA Approves Herceptin Biosimilar Kanjinti for HER2-positive Breast Cancer
This post was originally published on this site The U.S. Food and Drug Administration (FDA) has approved Amgen and Allergan’s Kanjinti (trastuzumab-anns), a biosimilar to Genentech’s Herceptin (trastuzumab), for all indications of its reference product — including as a treatment for HER2-positive breast cancer, the companies announced. A biosimilar is a biological medical product that is nearly identical…
‘Rare Barometer’ Program Helps Eurordis Shape EU Rare Disease Policy
This post was originally published on this site People with rare diseases know that the right government policies can make a big difference in the quality of their own lives, and those of their caregivers. But most lawmakers aren’t experts in even one well-known disease — let alone the world’s estimated 7,000 rare disorders. So…
Ygalo Continues to Induce Clinically Meaningful Responses in Relapsed or Refractory Multiple Myeloma, Phase 1/2 Trials Show
This post was originally published on this site Ygalo (melflufen) combination therapy continues to lead to clinically meaningful responses, without significant side effects, in patients with relapsed or refractory multiple myeloma, updated data from Phase 1/2 trials show. The new findings were presented in two posters, titled “ANCHOR (OP-104): A Phase 1 study update of…
Sentinel Node Biopsy Feasible to Determine Spread of Early-stage OC
This post was originally published on this site A sentinel node biopsy, used to determine whether cancer has spread to lymph nodes, is a feasible way to obtain information and avoid lymph node dissection in patients with early-stage ovarian cancer, a new study shows. The study, “Sentinel-Node Biopsy in Early Stage Ovarian Cancer: Preliminary Results…
Most Prostate Cancer Patients on Active Surveillance Don’t Follow Monitoring Guidelines, Study Shows
This post was originally published on this site Most prostate cancer patients who choose to undergo active surveillance instead of treatment are not receiving the appropriate disease monitoring, bringing into question whether or not this is a safe treatment option, according to a population-based study. The study, “Population-based cohort of prostate cancer patients on active…
Colorectal Cancer Vaccine Candidate Induces Potent Immune Responses, Interim Trial Results Show
This post was originally published on this site A single dose of PolyPEPI1018 — Treos Bio’s investigational off-the-shelf vaccine for colorectal cancer — induced promising immune responses and clinical signs of efficacy when given in combination with standard maintenance therapy in metastatic colorectal cancer patients, interim results from a Phase 1/2 trial show. The findings…
Forty Seven, Acerta Collaborate to Test Triple Combo Therapy on DLBCL Patients
This post was originally published on this site Forty Seven and Acerta Pharma are collaborating to test a triple combination of the investigational 5F9 plus Rituxan (rituximab) and Calquence (acalabrutinib) in patients with diffuse large B-cell lymphoma (DLBCL). The partnership builds on prior Phase 1b data that showed a combination of Forty Seven’s 5F9 and Rituxan was safe and…
Vaccine Reduces Tau Tangle Formation, Improves Cognitive Functioning in Alzheimer’s Mouse Model
This post was originally published on this site A vaccine produced using virus-like particles was able to improve cognitive functioning and reduce the accumulation of tau protein aggregates — a hallmark of Alzheimer’s disease — in a mouse model of the disease, a study shows. The study, “Qß Virus-like particle-based vaccine induces robust immunity and…
Kisqali-Endocrine Therapy Combo Increases Overall Survival In Hormone Receptor-Positive Breast Cancer Patients, Study Shows
This post was originally published on this site A combination of endocrine therapy and the targeted therapy Kisqali (ribociclib) is more effective than endocrine therapy alone at prolonging the survival of premenopausal women who have metastatic hormone receptor-positive breast cancer, a Phase 3 clinical trial suggests. Findings from the MONALEESA-7 trial (NCT02278120) were presented during…
FDA Grants Fast Track Status to Immunotherapy Candidate TRQ-1501 for Some Solid Tumors, Lymphomas
This post was originally published on this site TRQ-1501, an experimental immune cell cancer therapy developed by Torque, was granted Fast Track designation by the U.S. Food and Drug Administration (FDA) for the treatment of certain hard-to-treat solid tumors and lymphomas. The designation is given to therapies that show potential to treat serious health conditions,…
CT103A CAR T-cell Therapy Leads to Strong Anti-cancer Responses in Relapsed or Refractory Multiple Myeloma Patients, Trial Shows
This post was originally published on this site CT103A, a fully-human anti-B-cell mature antigen (BCMA) CAR T-cell therapy, leads to strong anti-cancer responses in patients with relapsed or refractory multiple myeloma, including those who relapsed after receiving prior CAR T-cell therapy, data from a trial shows. The findings were presented in a poster, titled “Clinical…