This post was originally published on this site Obesity in women with triple-negative breast cancer, the most aggressive kind of breast cancer, reprograms immune cells and creates a chronic inflammatory environment that promotes cancer progression and spread, a study has found. The study, “Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer,” was…
Conditions
Conditions
Trial Will Test Thermal Ablation, Followed By IP-001 Immunotherapy, Against Solid Tumors
This post was originally published on this site Immunophotonics and Clinical Laserthermia Systems (CLS) are teaming up in a Phase 1/2 trial to explore the safety and effectiveness of a thermal ablation approach — destruction of tissue by an extreme temperature increase — followed by injection into the tumor of the investigational IP-001, for treating…
FDA Lifts Hold on Phase 3 Trial Testing Venclexta in Myeloma Patients with Common Genetic Abnormality
This post was originally published on this site The U.S. Food and Drug Administration (FDA) has lifted its hold on the CANOVA Phase 3 clinical trial, which is evaluating the experimental therapeutic Vencexta (venetoclax) plus dexamethasone in people with relapsed or refractory multiple myeloma who test positive for a common genetic abnormality. Venclexta (sold as Venclyxto…
Zejula-Keytruda Trial Results Warrant Further Investigation for Recurrent OC
This post was originally published on this site A combination of Zejula (niraparib) and Keytruda (pembrolizumab) is well-tolerated and has promising anti-tumor activity in women with ovarian carcinoma who have failed prior platinum-based chemotherapy, results from a Phase 1/2 trial show. Overall, 18% of the patients responded to the combo regimen, regardless of platinum resistance,…
Liquid Biopsy Assay Being Utilized in Zejula Trials for PC
This post was originally published on this site A liquid biopsy assay called Resolution HRD is being used in Phase 2 and Phase 3 trials of Zejula (niraparib) to help screen key mutations in prostate cancer patients. Through a blood draw, Resolution Bioscience’s cell-free DNA (cfDNA) assay identifies mutations implicated in homologous recombination deficiency (HRD),…
TG Therapeutics to Seek Accelerated Approval of Umbralisib for Marginal Zone Lymphoma
This post was originally published on this site After positive feedback from the U.S. Food and Drug Administration, TG Therapeutics is planning to pursue accelerated approval for umbralisib (TGR-1202) as a treatment for patients with marginal zone lymphoma (MZL). The decision was supported by findings from the ongoing UNITY-NHL Phase 2b clinical trial (NCT02793583), in which…
Advantagene Reaches Enrollment Goal in Phase 2 Trial Testing Prostate Cancer Vaccine
This post was originally published on this site Advantagene, also known as Candel Therapeutics, has reached its patient enrollment goal in an ongoing Phase 2 trial testing the effectiveness of ProstAtak, the company’s prostate cancer vaccine, among men with localized prostate cancer who chose to remain on active surveillance. ProstAtack is a gene-mediated cytotoxic immunotherapy…
MemTrax, An Online Test, Helps Track Cognitive Problems in Alzheimer’s
This post was originally published on this site An online test, called MemTrax, may help screen and predict the progression of cognitive impairment in Alzheimer’s and other disorders, according to a new study using artificial intelligence. The research, “Episodic-Memory Performance in Machine Learning Modeling for Predicting Cognitive Health Status Classification,” was published in the Journal…
An Aging Population Creates Caregiver Fatigue
This post was originally published on this site Caregivers of a certain age may remember the late comedienne Lucille Ball’s “Vitameatavegamin“ sketch. The famous, very funny redhead asks: “Are you tired, rundown, listless? Do you poop out at parties?” For most caregivers, the answer is a resounding “yes,” perhaps especially for those who care for…
Balixafortide-Halaven Combo Seen to Prolong Survival in Advanced Breast Cancer Patients in Phase 1 Trial
This post was originally published on this site A combination of Polyphor‘s investigational therapy balixafortide (POL6326) and Eisai‘s Halaven (eribulin) may prolong the survival of women with HER2-negative metastatic breast cancer, a Phase 1 trial shows. The findings were presented in the poster “Balixafortide (a CXCR4 antagonist) + eribulin in HER2-negative metastatic breast cancer (MBC): Survival…
Libtayo Approved in Europe to Treat Metastatic or Advanced Cutaneous Squamous Cell Carcinoma
This post was originally published on this site Libtayo (cemiplimab) has been conditionally approved to be sold in the European Union for the treatment of adults with metastatic or locally advanced cutaneous squamous cell carcinoma (CSCC), one of the most common types of skin cancer. The decision of the European Commission (EC) makes Libtayo the…
Dosing Begins in Study of TP-0903, With or Without Imbruvica, for Advanced CLL and SLL
This post was originally published on this site Dosing with the investigational therapy TP-0903 has begun in patients with previously treated chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) in an ongoing Phase 1/2 trial, its developer, Tolero Pharmaceuticals, announced. The open-label study (NCT03572634) aims to recruit 108 patients who have failed to respond to prior therapies.…