This post was originally published on this site Inhibition of a protein called LIMK1 may help prevent the loss of dendritic spines — the connections between neurons in the brain — triggered by the build-up of beta-amyloid in early stage Alzheimer’s disease, a study has found. “This is the first study to showcase that inhibiting…
Conditions
Conditions
Trilaciclib-Chemo Combo Extends Lives of Triple-negative Breast Cancer Patients, Preliminary Phase 2 Findings Show
This post was originally published on this site Trilaciclib, a treatment that protects the bone marrow from the damaging effects of chemotherapy, significantly extends the lives of women with metastatic triple-negative breast cancer receiving a chemotherapy regimen of gemcitabine and carboplatin, G1 Therapeutics announced. Chemotherapy kills tumor cells that divide rapidly. However, a major side…
Transgene Completes Enrollment for Phase 2 Trial of Triple Combo NSCLC Therapy
This post was originally published on this site Transgene has completed patient enrollment for its Phase 2 trial evaluating the cancer vaccine TG4010 in combination with Opdivo (nivolumab) and chemotherapy as a first-line treatment for advanced non-squamous non-small cell lung cancer (NSCLC) with low or no expression of PD-L1. The first results regarding the trial’s…
Request for Darzalex as Faster and Easier Under-the-skin Infusion for Multiple Myeloma Before FDA
This post was originally published on this site Janssen has asked the U.S. Food and Drug Administration (FDA) to approve a new subcutaneous (under-the-skin) formulation of Darzalex (daratumumab) as a faster and easier treatment for people with multiple myeloma. Currently, Darzalex is approved as an intravenous infusion into a vein that takes several hours. The biologics license…
Blood Test Ably Identifies Ovarian Cancer Prior to Surgery, Clinical Trial Planned
This post was originally published on this site A blood test successfully identified ovarian cancer from circulating cells, and may enable this cancer to be detected early and prior to surgery, results of the first phase of a clinical verification study show. This first stage or pre-study was conducted at the University of Rochester Medical Center…
TRC253 Showing Effectiveness in Metastatic Castration-resistant Prostate Cancer Patients
This post was originally published on this site The potential oral therapy TRC253 was well-tolerated and showed effectiveness in a subset of patients with metastatic castration-resistant prostate cancer (mCRPC), according to results from the first part of a Phase 1/2a clinical trial. The second part of the study (NCT02987829) is currently enrolling at several U.S. locations…
Localized and Superficial Brain PCNS Lymphomas May Benefit from Surgery, Study Reviews Suggest
This post was originally published on this site Certain patients with primary central nervous system (PCNS) lymphoma, a rare type of brain cancer, may benefit more from having surgery to remove their tumor than following the current standard of care, which does not include surgery, a review of studies concludes. Until now, surgical resection has…
European Initiative Targets Diagnosis, Treatment of Rare Diseases
This post was originally published on this site A new international consortium based in Paris, and funded largely by the 28-member European Union, intends to speed the diagnosis of rare diseases, while also accelerating the development of treatments for the 95% of such illnesses that currently don’t have one. The European Joint Programme on Rare…
Myeloma UK Launches Research Program Focused on Trial Design
This post was originally published on this site In a continuing effort to support and advance early-phase multiple myeloma studies in the United Kingdom, Myeloma UK is launching a patient-focused research program. Called the UK Myeloma Research Alliance-Myeloma UK-Concept and Access Research Program (UKMRA-Myeloma UK-CARP), the grant initiative seeks to build upon the success of…
Liquid Biopsy Could Help Identify Aggressive Prostate Cancers, Study Says
This post was originally published on this site A non-invasive test that examines microRNAs — small RNA molecules — in urine may be used to identify aggressive prostate cancers with great accuracy, potentially avoiding unnecessary treatments for slow-growing cancers, a study suggests. The study, “Temporal stability and prognostic biomarker potential of the prostate cancer urine…
Healthy Lifestyle Choices May Lower Risk of Cognitive Decline and Alzheimer’s Dementia, Research Shows
This post was originally published on this site Healthy lifestyle choices — maintaining an active mind, a nutritious diet, and regular exercise — may help protect against cognitive decline and dementia, new research shows. Moreover, cigarette smoking and alcohol abuse seem to be associated with cognitive impairment and increased dementia risk. These are the main…
What to Do When Elderly Parents Deny They Have Alzheimer’s Disease
This post was originally published on this site An Alzheimer’s diagnosis is perhaps one of the most difficult to accept, and yet an estimated 50 million people around the globe have Alzheimer’s or related dementia. How many suffer from the disease but haven’t been diagnosed — or deny their diagnosis — is unclear. Described by…