Atuzaginstat (COR388), Cortexyme’s investigational oral therapy, effectively suppressed the activity of its target — toxic enzymes called gingipains — and was associated with reductions in several disease biomarkers in people with mild-to-moderate Alzheimer’s, according to updated data from the Phase 2/3 GAIN clinical trial. Similar to previously reported findings, these benefits were most pronounced among patients with high load of Porphyromonas gingivalis (P. gingivalis), a bacterium that produces gingipains, causes gum disease, and has been linked…
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